Centre for Arboviral and Zoonotic diseases

Mandate of the Division:

Centre for Arboviral And Zoonotic Diseases comprises of 9 National Reference Laboratory dealing with Zoonotic diseases of public health importance including outbreak prone and emerging infectious diseases. The role of the division is primarily to provide laboratory evidence by conducting special and reference level tests which are not available at most of the institutes or medical colleges in India. Currently the work is being carried out on the following Zoonotic diseases: Rabies, Kala-azar, Arboviral infections (Dengue, JE, Chikungunya, Zika virus & CCHF) Toxoplasmosis, Brucellosis, Leptospirosis, Rickettsiosis, Hydatidosis, Neurocysticercosis, Plague and Anthrax etc

CAZD is also involved in Plague surveillance and preparedness assisted with Plague surveillance unit, NCDC Bengaluru Branch.

 

Relevant Photograph of the Division

TRAINING ON PPE, SPILL MANAGEMENT & TRIPLE LAYER PACKING , 2019 PHOTOGRAPH OF CAZD (FORMERLY ZOONOSIS DIVISION) OFFICIERS AND OFFICIALS,
NCDC, DELHI, 2017 LABORATORY EXPERT GROUP MEETING FOR PROGRAMMES UNDER, DIVISION OF
ZOONOTIC DISEASE PROGRAMMES, 2021 HANDS ON TRAINING ON DIAGNOSTIC RICKETTSIOLOGY , 2020 BIOSAFTETY AND BIOSECURITY WORKSHOP UNDER HISICON-2021,
ORGANISED BY CAZD OFFICIER AND OFFICIALS OF ZOONOSIS DIVISION FORMED IN 1963 (PRESENTLY
KNOWN AS CENTRE FOR ARBOVIRAL AND ZOONOTIC DISEASES) 26th PLAUGE INTERSTATE MEETING CONDUCTED BY NCDC DELHI AND BANGLORE. ONE DAY WORKSHOP FOR UNDERSTANDING ARBOVIRAL AND ZOONOTIC DISEASES
CONDUCTED BY CAZD IN COLLABORATION WITH RAMJAS COLLEGE ON
THE OCCASION OF “NATIONAL SCIENCE DAY”, 2023 A CME ON ANIMAL BITE AND RABIES ORGANIZED AT LADY HARDINGE
MEDICAL COLLEGE & SMT. S.K. HOSPITAL, 2023

TRAINING ON PPE, SPILL MANAGEMENT & TRIPLE LAYER PACKING, 2019

PHOTOGRAPH OF CAZD (FORMERLY ZOONOSIS DIVISION) OFFICIERS AND OFFICIALS, NCDC, DELHI, 2017

LABORATORY EXPERT GROUP MEETING FOR PROGRAMMES UNDER, DIVISION OF ZOONOTIC DISEASE PROGRAMMES, 2021

HANDS ON TRAINING ON DIAGNOSTIC RICKETTSIOLOGY, 2020

BIOSAFTETY AND BIOSECURITY WORKSHOP UNDER HISICON-2021, ORGANISED BY CAZD

OFFICIER AND OFFICIALS OF ZOONOSIS DIVISION FORMED IN 1963 (PRESENTLY KNOWN AS CENTRE FOR ARBOVIRAL AND ZOONOTIC DISEASES)

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Publications :

• 1 Jayaprakasam M, Chatterjee N, Chanda MM, Shahabuddin SM , Singhai M,Tiwari S, Panda S. Human anthrax in India in recent times: A systematic review & risk mapping. One Health.Volume 16, June 2023, 100564. https://doi.org/10.1016/j.onehlt.2023.100564
• 2 Goyal R, Singhai M, Mahmood T, Saxena V. Association between the physical activity and metabolic syndrome in residents of a foot-hill area in India. Diabetes Metab Syndr. 2022 Mar 23;16(4):102471. doi: 10.1016/j.dsx.2022.102471
• 3 Agrawal SJ, Goyal R, Singhai M. Breakthrough Infections and Omicron Variant: Dealing with the Dilemma. Indian J Med Biochem 2021; 25 (3):0-0.
• 4 Singhai, M.; Sood, V.; Singh, G.; Siddiqui, C.; Nale, T.; Jha, P.; Yadav, P.; Jaiswal, R.; Bala, M.; Singh, S.K.; Tiwari, S. Rabies Outbreak in the Urban Area of Delhi: An Investigation Report and One Health Perspective for Outbreak Management. Infect. Dis. Rep. 2022, 14, 1033-1040.
• 5 Singhai M, Sood V, Yadav P, Kumar KK, Jaiswal R, Madabhushi S, Dhull P, Bala M, Singh SK, Tiwari S. Intravitam Diagnosis of Rabies in Patients with Acute Encephalitis: A Study of Two Cases. Infect Dis Rep. 2022 Nov 29;14(6):967-970. doi: 10.3390/idr14060095. PMID: 36547241; PMCID: PMC9778139.
• 6 Singhai, M., Shah, Y. D., Gupta, N., Bala, M., Kulsange, S., Kataria, J., & Singh, S. K. (2021). Chronicle down memory lane: India’s sixty years of plague experience. Indian Journal of Medical Microbiology.
• 7 Singhai M, Jaiswal R, Siddiqui C, Tiwari S, Gupta N, Bala M, Singh SK. Rabies can be a disease of puppyhood. J Family Med Prim Care. 2022 Jun;11(6):3339-3341. doi: 10.4103/jfmpc.jfmpc_1605_21. Epub 2022 Jun 30. PMID: 36119256; PMCID: PMC9480633.
• 8 Arora, R., Goel, R., Singhai, M., Gupta, N., & Saxena, S. (2021). Rabies Antigen Detection in Postmortem Cornea. Cornea, 40(5), e10-e11.
• 9 Singhai, M., Dhariwal, A. C., Gupta, N., Goswami, S., & Singh, S. K. (2020). An Observational Study of JE Cases Detected in National Centre for Disease Control from January 2017 to December 2019. Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138), 52(4), 12-16.
• 10 Gupta, N., Singhai, M., Garg, S., Shah, D., Sood, V., & Singh, S. K. (2020). The missing pieces in the jigsaw and need for cohesive research amidst coronavirus infectious disease 2019 global response. medical journal armed forces india, 76(2), 132-135.
• 11 Jaiswal¹, R., Chhabra, M., Singh, P., Gupta, N., Singhai, M., Dhariwal, A. C., & Tripathi, P. (2018). Molecular Epidemiology and Sequence Analysis of Rabies Virus Isolates from North and North East India. Journal of Communicable Diseases, 50(4), 4
• 12 Singh, G., Chhabra, M., Singh, P., Gupta, N. K., Singhai, M., Dhariwal, A. C., & Ram, S. (2018). Molecular Study of Glycoprotein (G) Gene Region of Rabies Virus from Spotted Deer, Delhi, India. Journal of Communicable Diseases, 50(3), 3.
• 13 Singh, G., Jaiswal, R., Chhabra, M., Sood, Y., Gupta, N., Singhai, M., Tiwari, S., Dhariwal, A.C., Sharma, R. and Ram10, S. (2017). Evaluation of Direct Rapid Immunohistochemistry Test (DRIT) for Postmortem Diagnosis of Rabies. Journal of Communicable Diseases, 49(3), 3.
• 14 Rawat, V., Kumar, A., Kumar, M., Singhai, M., Rawat, C. M. S., & Jha, S. K. (2016). Viral Hepatitis A and E Outbreaks in Kumaon Region of Uttarakhand. National Academy Science Letters, 39(1), 17-19.
• 15 Singhai, M., Rawat, V., Singh, P., & Goyal, R. (2016). Fatal case report of concomitant hepatitis E and Salmonella paratyphi A infection in a sub-Himalayan patient. Annals of Tropical Medicine & Public Health, 9(1).
• 16 Malik, Y. P. S., Kumar, N., Rawat, V., Sharma, K., Kumar, A., Singhai, M., & Kumar, M. (2015). Detection and distribution pattern of prevalent genotypes of hepatitis-C virus among chronic hepatitis patients from Kumaon region of Uttarakhand, India. Indian journal of medical microbiology, 33, 161.
• 17 Mittal, V., Chhabra, M., & Venkatesh, S. (2015). Ebola virus-an Indian perspective. The Indian Journal of Pediatrics, 82(3), 207-209.
• 18 Sharma, P., Mittal, V., Chhabra, M., Singh, P., Bhattacharya, D., & Venkatesh, S. (2014). Dominance shift of DENV-1 towards reemergence and co-dominant circulation of DENV-2 & DENV-3 during post-monsoon period of 2012 in Delhi, India. Journal of Virology and Retrovirology, 1(1), 104.
• 19 Shrivastava, A., et al (2015). Outbreaks of unexplained neurologic illness—Muzaffarpur, India, 2013–2014. MMWR. Morbidity and mortality weekly report, 64(3), 49.
• 20 Sharma, P., Mittal, V., Chhabra, M., Kumari, R., Singh, P., & Venkatesh, S. (2016). Molecular epidemiology and evolutionary analysis of dengue virus type 2, circulating in Delhi, India. Virusdisease, 27(4), 400-404.
• 21 Singh, P., Chhabra, M., Sharma, P., Jaiswal, R., Singh, G., Mittal, V., Rai, A. and Venkatesh, S. (2016). Molecular epidemiology of Crimean-Congo haemorrhagic fever virus in India. Epidemiology & Infection, 144(16), 3422-3425.
• 22 Singh, P., Sharma, P., Kumar, S., Chhabra, M., Rizvi, M.A., Mittal, V., Bhattacharya, D., Venkatesh, S. and Rai, A. (2016). Continued persistence of ECSA genotype with replacement of K211E in E1 gene of Chikungunya virus in Delhi from 2010 to 2014. Asian Pacific Journal of Tropical Disease, 6(7), 564-566.
• 23 Thakur, R., Kumar, Y., Singh, V., Gupta, N., Vaish, V. B., & Gupta, S. (2016). Serogroup distribution, antibiogram patterns & prevalence of ESBL production in Escherichia coli. The Indian journal of medical research, 143(4), 521.
• 24 Kumar, Y., Gupta, N., Vaish, V. B., & Gupta, S. (2016). Distribution trends & antibiogram pattern of Salmonella enterica serovar Newport in India. The Indian journal of medical research, 144(1), 82.

Operational Research

1. To study the epidemiological profile of Kala-azar patients in Delhi
2. Serological studies in Toxoplasmosis in different Delhi Hospitals.
3. Comparative analysis of various serological tests in diagnosis of Toxoplasmosis.
4. Surveillance of Plague in different parts of the country.
5. Molecular characterisation of strains of Leishmania.
6. Standardization of appropriate diagnostic methods for sero-diagnosis and sero-epidemiology of leptospirosis.
7. Surveillance of arboviral infections in man and animals.
8. Study of prevalence of Rabies in peridomestic and wild rodents.
9. Standardization of Rapid Fluorescent Focus Inhibition Test (RFFIT) for rabies antibody titer.
10. Serological studies in clinically suspected cases of hydatid disease.
11. Sero-epidemiological studies for rickettsial diseases (scrub typhus & Indian tick typhus) in patient with pyrexia of unknown origin.

Technical Guidelines

• National Guidelines for Rabies Post exposure prophylaxis 2019

• National Guidelines for Rabies Post exposure prophylaxis 2015.
• National Guidelines : Diagnosis, Case Management, Prevention & control of leptospirosis.

Technical reports/Communicable Disease alerts:

1. Glanders
2. ⁠Kyasanur forest Disease: A Public Health Concern
3. Meliodosis
4. Scrub Typhus
5. ⁠Zika Virus Disease

Manuals:

1. Manual on Zoonotic Diseases of Public Health Importance
2. Rabies General Aspects Laboratory Techniques 2022

National Referral Laboratories/Units under Division:

A) ROUTINE REFERRAL DIAGNOSTIC SERVICES

Notes: